33 articles - From Friday Dec 15 2023 to Friday Dec 22 2023
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| J Crohns Colitis |
|---|
The Impact of Dietary Interventions on the Microbiota in Inflammatory Bowel Disease: A Systematic Review. Diet modulates the gut microbiota, and this may have implications for IBD; however, the body of evidence does not currently support clear dietary patterns or food constituents that are associated with a specific microbiota profile or disease marker in IBD patients. Further research is required with a focus on robust and consistent methodology to achieve improved identification of associations. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
|---|
Effect of cocoa extract supplementation on cognitive function: results from the clinic subcohort of the COSMOS trial. Among 573 older adults who underwent repeat in-person, detailed neuropsychological assessments over 2 y, daily CE supplementation, compared with placebo, showed no overall benefits for global or domain-specific cognitive function. Possible cognitive benefits of CE among those with poorer diet quality warrant further study. |
Effects of Chinese Heart-Healthy Diet on Blood Lipids, Glucose and Estimated 10-year Cardiovascular Risk Among Chinese Adults: Results on Secondary Outcomes of a Randomized Controlled Trial. The CHH diet reduced TC and 10-year cardiovascular risk and was likely to reduce blood glucose among Chinese adults with mild hypertension. Further studies with longer term are warranted. |
Fish consumption and omega-3 polyunsaturated fatty acids from diet are positively associated with cognitive function in older adults even in the presence of exposure to lead, cadmium, selenium, and methylmercury: a cross-sectional study using NHANES 2011 - 2014 data. Our findings support dietary recommendations for older adults to consume fish to maintain cognitive function, likely due to biomolecular actions of |
Food, nutrition, and fertility: from soil to fork. Participants developed research proposals to address the priority evidence gaps. The workshop findings serve as a foundation for future prioritization of scientific research to address evidence gaps related to food, nutrition, and fertility. |
High-dose vitamin D3 supplementation in pregnancy and risk of neurodevelopmental disorders in the children at age 10: A randomized clinical trial. Higher maternal preintervention 25(OH)D was associated with a decreased risk of autism, lower autistic symptom load, and decreased risk of ADHD diagnosis, but high-dose vitamin D3 supplementation in pregnancy had no effect on risk of autism and ADHD. |
Intake and biomarkers of folate and folic acid as determinants of chemotherapy-induced toxicities in patients with colorectal cancer: a cohort study. This study suggests a potential association between folic acid and capecitabine-induced toxicities, providing a rationale to study diet-drug interactions and raise further awareness of the use of dietary supplements during oncological treatment. Clinical trial details |
| Inflamm Bowel Dis |
Factors Associated With Extraintestinal Manifestations of Inflammatory Bowel Disease in SPARC-IBD. This is the first comprehensive large-cohort assessment of how EIMs relate to one another at the individual vs systems levels. Further, our analysis is the first to recognize specific locations of colon involvement associated with EIMs of IBD, regardless of IBD type. These results are important in identifying patients at risk of developing future EIMs and may help with risk stratification when choosing treatments. |
Fungal Microbiota Composition in Inflammatory Bowel Disease Patients: Characterization in Different Phenotypes and Correlation With Clinical Activity and Disease Course. This study shows important differences in the mycobiome in IBD and within phenotypes. Selected fungal species were associated with complicated disease and the need of surgery in CD. This work adds to our understanding of the role of fungi in IBD, with potential clinical implications. |
Phosphoproteomics Reveals Novel Insights into the Pathogenesis and Identifies New Therapeutic Kinase Targets of Ulcerative Colitis. Our research deepened the understanding of UC pathogenesis through the lens of phosphorylation. Moreover, we identified CDK2 as a new potential therapeutic target for UC, revealing a novel role for CDK2 in necroptosis. |
| J Crohns Colitis |
Efficacy and Safety of the Anti-Mucosal Addressin Cell Adhesion Molecule-1 Antibody Ontamalimab in Patients with Moderate-to-Severe Ulcerative Colitis or Crohn's Disease. Ontamalimab 75 mg was effective with no safety concerns as induction and maintenance therapy for patients with moderate-to-severe ulcerative colitis. |
Epigenetic and metabolic reprogramming of fibroblasts in Crohn's disease strictures reveals histone deacetylases as therapeutic targets. Increased HDAC expression profiles, H3K27ac hypoacetylation, a significant glycolytic phenotype, and metabolic priming, characterise SCD-derived as compared to NSCD fibroblasts. Our results reveal a novel epigenetic component to Collagen-I regulation and TGFß-mediated CD fibrosis. HDAC inhibitor therapy may 'reset' the epigenetic changes associated with fibrosis. |
Risankizumab Induction Therapy Achieves Early Symptom Improvements That Are Associated With Future Clinical and Endoscopic Outcomes in Crohn's Disease: Post Hoc Analysis of the ADVANCE, MOTIVATE, and FORTIFY Phase 3 Studies. After the first intravenous RZB induction dose, significantly greater rates of symptom improvement versus PBO were achieved. Improvements could be observed as early as week 1 and were predictive of week 12 and 52 clinical and endoscopic improvement. |
| Liver Transpl |
Development of a model to predict the risk of early graft failure after adult-to-adult living donor liver transplantation: An ELTR study. The model also stratified long-term graft survival (p<0.001), which ranged from 87% in the low risk group to 60% in the high risk group. In conclusion, based on a panel of donor and recipient variables, an ANN can contribute to decision making in ALDLT by predicting EGF risk. |
Discarded livers tested by normothermic machine perfusion in the VITTAL trial: Secondary end points and 5-year outcomes. This first report of long-term outcomes of high-risk livers assessed by normothermic machine perfusion demonstrated excellent 5-year survival without adverse effects in al organs functioning beyond 1 year (ClinicalTrials. gov number NCT02740608). |
Financial burden after liver transplantation is significant among commercially insured adults: A large U.S. National Cohort. In a large national cohort of commercially insured LT recipients, financial liability was highly variable across sociodemographic and clinical characteristics; nearly 1 out 2 LT recipients owed>$5K for 1 year of post-LT care. Transplant programs should help patients anticipate potential costs and identify vulnerable populations who would benefit from enhanced financial counseling. |
Neighborhood-level social determinants of health measures independently predict receipt of living donor liver transplantation in the U.S. Of the 24 neighborhood-level SDoH measures studied, the SDI was most different between the two transplant types, with LDLT recipients having lower SDI (i. e., less socioeconomic disadvantage) than DDLT recipients (median SDI 37 vs 47; p 40. |
Waitlist and post-transplant outcomes of pregnancy-related acute liver failure in the United States. In this UNOS database analysis of ALF among women of childbearing age, the waitlist outcome is better in women with P-ALF compared to NP-ALF. Among women with P-ALF, the 90-day WLM is worse for HELLP vs AFLP. Further studies are needed to improve the management of HELLP and prevent the development of ALF in this subgroup population. |
| Pancreatology |
Opportunistic screening for osteopathy with routine abdominal computed tomography scan in chronic pancreatitis. Abdominal CT images, which are routinely performed in chronic pancreatitis, can be used for opportunistic screening of osteoporosis and osteopenia without additional cost or radiation exposure. |
Prognostic impact of the distance from the root of splenic artery to tumor in the patients with pancreatic body or tail cancer. DST did not affect prognosis in patients with pancreatic body/tail cancer. Neoadjuvant therapy followed by DP may be desirable for patients with a DST = 0 tumor. For those with a 0 |
Reconsidering resectable oncological conditions in pancreatic tail cancer: A multicenter retrospective study on prognostic factors in pancreatic tail cancer after resection (HOPS Pt-01). The MLM identified certain Pt-PC cases warranting consideration beyond resectable during clinical management. Particular attention should be paid to conditions requiring CVR, even though immortal time bias remains unresolved with adjuvant treatment. |
Understanding the role of frailty in local and systemic complications and healthcare resource utilization in acute pancreatitis: Findings from a national cohort. Frailty in AP patients is linked to elevated rates of local and systemic complications, increased mortality, and higher healthcare costs. Assessing frailty is crucial in AP management as it provides a valuable tool for risk stratification and identifying high-risk patients, thereby improving overall outcomes. |
Plenty of the editorials are available as full text through the publisher website using the provided link
misc publications eg case reports, tools of the trade, images of the month, etc…
| Liver Transpl |
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| Pancreas |
Letters to the editors and authors’ replies